10-month-old from Malaysia undergoes liver transplant

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The child underwent a host of surgeries at Indraprastha Apollo Hospital

A 10-month-old, baby Noor, from Malaysia, has successfully undergone liver transplant at Indraprastha Apollo Hospital. Noor soon after birth had developed jaundice that advanced with time and was further diagnosed with biliary atresia, a rare liver and bile disease which has a ratio of 1 : 12000 in  infants worldwide. In addition to this, the baby also had heterotaxy, an abnormal arrangement of the internal thoracic-abdominal organs across the left-right axis of the body. Her liver and stomach are in the middle of the abdomen and her heart was in the middle of the chest.

The child underwent a Kasai surgery that connects the under surface of liver directly to the intestines to achieve biliary drainage. She also underwent abdominal surgery to correct intestinal malrotation. However, both the surgeries were unsuccessful.

According to Dr Anupam Sibal, Group Medical Director, Apollo Hospitals Group and Senior Paediatric Gastroenterologist & Hepatologist, Indraprastha Apollo Hospitals, “If Kasai surgery fails to clear jaundice, then the only treatment is a liver transplant. Noor fell into this category of failed Kasai and developed progressive liver failure leading to severe jaundice, a bloated belly with ascites, growth failure, bleeding episodes due to liver dysfunction and increased pressure in the veins supplying her hardened liver. She was hospitalised in Kuala Lampur multiple times, during her treatment she suffered a massive gastro-intestinal bleed in February, leading to a near death like situation. Initially her transfer to India was cancelled as she was on ventilator but since it was a very high-risk case requiring immediate surgery, she was referred to us.”

Accordingto Dr Neerav Goyal, Senior Consultant and Head, Apollo Liver Transplant, Hepatobiliary and Pancreatic Surgery Unit, Indraprastha Apollo Hospitals, “The day after the family  landed in Delhi, an advisory was issued by the Government of India to quarantine all travellers from Malaysia for a minimum of two weeks. It was an ethical dilemma for the team of doctors and nurses, as we were not hopeful that Noor could survive so long without immediate treatment.  The team acted quick and put the family in quarantine, for a period of two weeks post which the liver transplant was planned.”

“Meanwhile Noor developed a rhythm disturbance with a very slow heart rate while awaiting a transplant. She immediately required a temporary pacemaker.  Post the quarantine period, after testing for SARS-COV- 2 which was negative and taking all precautions including PPE, she underwent a living related liver transplant.  The donor was her mother. At the time of the transplant, Noor had a bilirubin level of about 45 mg/dl as against a normal of less than one. Her weight was only 6.5 kg at the age of 9 months,” said, Dr Smita Malhotra, Consultant, Paediatric Gastroenterologist & Hepatologist, Apollo Hospitals, Apollo Hospitals Delhi.


Apollo HospitalMalaysia
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